Received: 01-10-2018 / Accepted: 14-04-2019
The objective of the present study was to determine the safety and efficacy of vaccine Han-Streptila incommercialtilapia by injection (in Hau Giang, Tien Giang and Dong Thap provinces) and by oral route (in An Giang, Vinh Long and Dong Thap provinces). The control, immune and safe groupswere set up in each province. The safety of the vaccine was determined by observing the abnormalities of experimental fish; the efficacy of the vaccine was determined by comparing the final cumulative mortality between thevaccinated groupandthe control group during the trial or after challenge test. This also was evaluated throughrelative percentage survival(RPS).The results showed that the vaccine hadno effect on mortality and growth of fish. Thevaccineefficacy through injection with tilapia of 10g/p achieved 66.9% and oral route for fish 2.5g/p achieved 63.9% protection after 24 weeks. Therefore,HAN-STREPTILA vaccine tested in the South of Vietnam wassafe and highly effective.