The objectives of the research were todetermine: (i) N, P,and K contentsof rice plantsand (ii) uptake requirements for N, P,and K to produce rice grain in dry and wet seasonsin Mekong Delta acid sulfate soils. Field demonstration plots of 1.000m2were conducted on acid sulfate soils located atfive locations in the Mekong Delta, during the wet season (WS) 2015 and the dry season (DS) of 2015-2016. The locations were Phung Hiep- Hau Giang, Hon Dat- Kien Giang, Hong Dan-Bac Lieu, Long My-Hau Giang, and Thap Muoi-Dong Thap. For each location, three farm plots with the same soil type were selected. Results showed thatthe average contentsof N, P, K in the grains were 1.08% N, 0.44% P2O5, 0.33% K2O, respectively. The figures f in rice straw were 0,62% N, 0,27% P2O5, 1,67% K2O, respectively.To produce one ton of grain, the rice plant took-up 17 kg N - 7 kg P2O5and 20 kg K2O. The average rice yield in the wet season was 5.0 tha-1andin dry season was 7.0 t ha-1.In the case without return ofrice straw into the soil, the amount of N, P, K removed by rice grain was 54 kgN - 22 kg P2O5- 16,5 kg K2O, in WS and75,6 kg N - 30,8 kg P2O5- 23,1 kg K2O in DS.