Pathogenesis of Hp-Prrsv in Crossbred Wild Pigs through Experimental Innoculation

Received: 23-11-2018

Accepted: 05-03-2019

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Issue: Vol. 17 No. 1 (2019)

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CHĂN NUÔI – THÚ Y – THỦY SẢN

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Duy, D., & Huynh, N. (2024). Pathogenesis of Hp-Prrsv in Crossbred Wild Pigs through Experimental Innoculation. Vietnam Journal of Agricultural Sciences, 17(1), 47–54. http://testtapchi.vnua.edu.vn/index.php/vjasvn/article/view/531

Pathogenesis of Hp-Prrsv in Crossbred Wild Pigs through Experimental Innoculation

Do Tien Duy (*) 1 , Nguyen Pham Huynh 1

  • 1 Khoa Chănnuôi Thú y, Đại học Nông Lâm thành phố Hồ Chí Minh

    • Keywords

    Pathogenesis, HP-PRRSV, crossbred wild-pigs

    Abstract


    The objective of this study was to examine the pathogenesis of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in crossbred-wild pigs through experimentally infected model. Twenty eight healthy crossbred-wild pigs, 42-49 day-old, originated from CSFV-PRRSV-negative farms were allocated in two experimental groups.The findings in clinical signs and pathology showed that the acute phase of infection took place from 5 to 14 days post infection. The major manifestations were fever, anorexia, respiratory failure, eye discharge and swelling, shivering and death. Severe interstitial pneumonia happened in all infected animals and interstitial pneumonia accompanied with hemorrhage recorded in died pigs. The laboratory indicators (viremia in the blood/tissues, IHC score, IgG antibodies, IL-1) were in homology with clinical pathology in acute phase of the disease. There were variations ofthe antigen distribution in various tissues over time-points post infection. This virus was first detected intheepithelial cells of bronchioles, stomach, kidney, bile duct and hepatic cells. The study results demonstrated that HP-PRRSV might cause severe pathology, wide antigenic distribution in visceral organs and could be fatal in crossbred-wild pigs through experimental infection.

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