The study was carried out from June 2021 to May 2022 to investigate the usage and bioactive compounds of indigenous plants commonly used in pig production. A total of 120 pig raising households in 3 provinces Hai Duong, Bac Giang, and Hoa Binh in Northern Vietnam were selected for interview using the preprepared questionnaires. After the survey, 16 potential plant species from studied regions were collected for determining their bioactive compounds and antioxidant capacity. Results showed that thirty-nine indigenous plant species were used as feed supplement for raising pigs in surveyed households, in which 5 indigenous plants, viz.Ipomoea batatas(86.67%), Bidens pilosa(55.83%), Uurena lobata(48.33%), Pseuderanthemum palatiferum(42.50%), and Wedelia chinensis(41.67%) were mainly used. Indigenous plants were used for different purposes such as improving animal health (69.12%), anti-inflammatory agents (41.03%), providing dietary fiber (38.46%), treatting diarrhea disease (28.21%), and enhancing animal product quality (25.64%). The higher content of polyphenols was found in 5 indigenous plants, i.e. Camellia sinensis, Manilkara zapota, Mangifera indica, Phyllanthus urinaria,and Psidium guajava, with polyphenol content ranging from 15.43 to 120.8 mgGAE/g DM. Moreover, 5 indigenous plants having stronger antioxidant activity were Camellia sinensis, Phyllanthus urinaria, Psidium guajava, Mangifera indica, and Ramalus cinnamomiand they showed better DPPH free radical scavenging activity with IC50 values less than 11.83 μg/ml. The research could serve as basis for selecting potential plants as herbs containing high polyphenol content and antioxidant activity for testing on live animals for various purposes.