Hepatoprotective Activities of Moringa Boiled (Moringa oleifera) Aqueous Waterin Balb/C Mice Model with Liver Injury Induced by Carbon Tetrachloride (CCl4)

Received: 05-01-2017

Accepted: 07-04-2017

DOI:

Views

0

Downloads

0

Issue: Vol. 15 No. 2 (2017)

Section:

KỸ THUẬT VÀ CÔNG NGHỆ

How to Cite:

Mien, P., Thai, T., Gioi, D., Huong, B., & Thao, D. (2024). Hepatoprotective Activities of Moringa Boiled (Moringa oleifera) Aqueous Waterin Balb/C Mice Model with Liver Injury Induced by Carbon Tetrachloride (CCl4). Vietnam Journal of Agricultural Sciences, 15(2), 225–233. http://testtapchi.vnua.edu.vn/index.php/vjasvn/article/view/355

Hepatoprotective Activities of Moringa Boiled (Moringa oleifera) Aqueous Waterin Balb/C Mice Model with Liver Injury Induced by Carbon Tetrachloride (CCl4)

Phi Thi Cam Mien (*) 1, 2, 3 , Tran Van Thai 4 , Dong Huy Gioi 3 , Bui Thi Thu Huong 3 , Do Thi Thao 5

  • 1 Khoa Nông học, Trường Đại học Nông nghiệp Hà Nội
  • 2 Khoa Công nghệ Sinh học, Trường Đại học Nông nghiệp Hà Nội
  • 3 Học viện Nông nghiệp Việt Nam
  • 4 Công ty cổ phần Dược phẩm quốc tế
  • 5 Viện Công nghệ sinh học, Viện Khoa học và Công nghệ Việt Nam

    • Keywords

    Liver protection, carbon tetrachloride, Moringa oleifera, root extract

    Abstract


    This study was conducted to evaluate the hepatoprotective and antioxidant effects of the root extract (RE) of Moringa oleifera. BALB/c mice were induced for liver damage by carbon tetrachloride in and subsequently administered by RE as a protection. In the experiments, the RE and silymarin were used at the doses of 0,5 ml (2,0 gram root powder) and 50 mg per kg of body weight, respectively. The results showed that after 14 days of administration, a reduction of the level of liver enzymes AST, ALT, LDH and total bilirubin was observed similar to the case of silymarin. Micro and macro-analysis of liver showed positive effects of both RE and silymarin in liver protection. This study suggested the potential application of RE in liver protection.

    References

    Amina E. Essawy, Ashraf M. Abdel-Moneim, Latifa I. Khayyat, Aglal A. Elzergy. (2012). Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice. Journal of Applied Pharmaceutical Science, 2(10): 21-25.

    Ashraf J., Nagma J.S., Mirani N., Rub A. (2012). Protective effect of rutin against carbon tetrachloride-induced hepatotoxicity in mice. International Journal of Drug Development and Research, 4(2): 352-357.

    Cui Y., Yang X., Lu X., Chen J., Zhao Y. (2014). Protective effects of polyphenols-enriched extract from Huangshan Maofeng green tea against CCl4-induced liver injury in mice,Chemico Biological Interactions, 220(5): 75-83.

    Choi K.C., Chung W.T., Kwon J.K., Yu J.Y., Jang Y.S., Park S.M., Lee S.Y., Lee J. (2010) Inhibitory effects of quercetin on aflatoxin B1 induced hepatic damage in mice, Foodand Chemical Toxicology, 48(10): 2747-2753.

    Dianzani M.U., Muzia G., Biocca M.E., Canuto R.A. (1991). Lipid peroxidation in fatty liverinduced by caffeine in rats, Int. J. Tissue React., 13(1): 79-85.

    Girish C., Koner B.C., Jayanthi S., Rao K.R., Rajesh B., Pradhan S.C (2009). Hepatoprotective activity of six polyherbal formulation in CCl4, induced liver toxicity in mice, Indian Journal of Experimental Biology, 47: 257-263.

    Muriel P., Garciapina T., Perez-Alverez V., Mourelle M. (1992). Silymarin protects against CCl4 - induced liver peroxidation and liver damage. J Appl Toxicol., 12: 439-442.

    Mohanraj S., Sangameswaran B., Santhosh K.C., Vinoth K.S., Atul N.C. (2013). Hepatoprotective effect of leaves of Morinda tinctoria Roxb. againstparacetamol induced liver damage in rats, Drug Invention Today, 5(3): 223-228.

    Muhammad N., Imtiaz H., Saima I. (2013). Antioxidant Potential of Moringa oleifera Leaf Extract for the Stabilisation of Butter at Refrigeration Temperature, 31(4): 332-339.

    Narayan P. Yadava, Anirban Pal Karuna Shanker, Dyaneshwar U. Bawankule, Anil K. Gupta, Mahendra P. Darokar, Suman P.S Khanuja (2008). Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4, induced hepatotoxicity in Rattus norvegicus. Phytomedicine, 15: 1053-1061.

    Ohkawa H., Ohishi N., Yagi K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem.,95: 351-358.

    Pari L., Murugan P. (2004). Protective role of tetrahydrocurcumin against erythromycin estolateinduced hepatotoxicity. Pharmacological Research, 4(5): 481-486.

    Peng K., Lan L.S, Yan W.X., Jie S.L., Wu Y.J., Hua Z.Y., Shu-Chen L. (2012). Polyporus umbellatus polysaccharides ameliorates carbon tetrachloride-induced hepatic injury in mice. African Journal of Pharmacy and Pharmacology, 6(37): 2686-2691.

    Phukan B., Kakoti B., Verma V.K., Kumar A. (2014). Hepatoprotective Activity of Justicia gendarusa Linn. Leaves in Carbon Tetrachloride Induced Liver Injury in Mice. Journal of Natural Remedies, 14(2): 132-137.

    Shi Y., Sun J., He H., Guo H., Zhang S. (2008). Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine induced liver injury in mice, Journal of Ethnopharmacology, 117(3): 415-419.

    Sreelatha S., Padma PR. (2009). Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity, 16(3): 149-157.

    Sreelatha S., Padma P. R. (2009). Antioxidant Activity and Total Phenolic Content of Moringa oleiferaLeaves in Two Stages of Maturity, 4(3): 321-336.

    Tamura A., Sasaki M., Yamashita H., Matsui Y. I., Saku T., Hikima T., Tabuchi M.,

    Munakata H. (2013). Kojima Y. A. - Yerba-mate (Ilex paraguariensis) extract prevents ethanolinduced liver injury in rats, Journal of Functional Foods, 4: 1714-1723.

    Trần Bảo Nguyễn Vinh Trần Quang, Khôi Nguyễn Ngọc(2011). Tác dụng chống oxi hóa và bảo vệ gan của lá cây chùm ngây (Moringa oleifera). Tạp chí dược học, 5: 421-425.

    Vusumzi P., Ewa C., Luke C. (2013). Comparison of antioxidant activity of Moringa oleiferaand selected vegetables in South Africa, 109(3/4), Art. #1154-1159.

    Xie Q., Guo F., Zhou W. (2012). Protective effects of cassia seed ethanol extract against carbon tetrachloride-induced liver injury in mice. Acta Biochimica Polonica, 59(2): 265.