Received: 25-05-2012
Accepted: 15-08-2012
DOI:
Views
Downloads
How to Cite:
Health-Benificial Properties of Milk Fat Globule Membrane Components
,
Bui Van Mien
1
Keywords
Anti-adhesion, anticancinogenic, brain development, glycoproteins, inhibition of infection, milk fat globule membrane, polar lipids
Abstract
In milk, lipids occur in the form of globules with diameters varying from 0.1 to 15 μm. These fat globules have a surrounding thin film which is called the milk fat globule membrane (MFGM). Fat in the core of the globules is mainly composed of neutral triacylglycerides while the lipid moiety of the MFGM fraction mainly consists of polar lipids. The protein moiety of the MFGM also has a specific composition with mainly glycosylated proteins, which are greatly different from those in milk plasma. Milk contains as little as 2 g/L of MFGM material. However, this material received much attention in recent years due to both its health-beneficial properties and technological functionalities. This paper compiles up-to-date knowledge concerning the health-beneficial effects from consumption of MFGM components. In addition, basic knowledge about composition and structure of MFGM is also briefly discussed.
References
Andersen M. H., L. Berglund, J. T. Rasmussen và T. E. Petersen (1997). Bovine PAS-6/7 Binds αVβ5Integrin and Anionic Phospholipids through Two Domains. Biochemistry 36(18):5441-5446.
Anonymous (2008). Phosphatidylserine. Monograph. Altern Med Rev 13(3):245-247.
Berra, B., I. Colombo, E. Sottocornola và A. Giacosa (2002). Dietary sphingolipids in colorectal cancer prevention. European Journal of Cancer Prevention 11(2):193-197.
Blusztajn J. K. (1998). Developmental neuroscience - Choline, a vital amine. Science 281(5378):794-795.
Boddaert J., K. Kinugawa, J. C. Lambert, F. Boukhtouche, J. Zoll, R. Merval, O. Blanc-Brude, D. Mann, C. Berr, J. Vilar, B. Garabedian, N. Journiac, D. Charue, J. S. Silvestre, C. Duyckaerts, P. Amouyel, J. Mariani, A. Tedgui và Z. Mallat (2007). Evidence of a role for lactadherin in Alzheimer's disease. Am. J. Pathol. 170(3):921-929.
Bojsen A., J. Buesa, R. Montava, A. S. Kvistgaard, M. B. Kongsbak, T. E. Petersen, C. W. Heegaard và J. T. Rasmussen (2007). Inhibitory Activities of Bovine Macromolecular Whey Proteins on Rotavirus Infections In Vitro and In Vivo. J. Dairy Sci. 90(1):66-74.
Bu H.-F., X.-L. Zuo, X. Wang, M. A. Ensslin, V. Koti, W. Hsueh, A. S. Raymond, B. D. Shur và X.-D. Tan (2007). Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. J. Clin. Invest. 117(12):3673-3683.
Campagna S., A. G. Mathot, Y. Fleury, J. M. Girardet và J. L. Gaillard (2004). Antibacterial Activity of Lactophoricin, a Synthetic 23-Residues Peptide Derived from the Sequence of Bovine Milk Component-3 of Proteose Peptone. J. Dairy Sci. 87(6):1621-1626.
Chandan R. C., J. Cullen, Ladbrook.Bd và D. Chapman (1971). Physicochemical Analyses of Bovine Milk Fat Globule Membrane .1. Differential Thermal Analysis. J. Dairy Sci. 54(12):1744-1751.
Clandinin M. T., E. J. Park, M. Suh, B. Thomson, A. B. R. Thomson và K. S. Ramanujam (2005). Dietary ganglioside decreases cholesterol content, caveolin expression and inflammatory mediators in rat intestinal microdomains. Glycobiology 15(10):935-942.
Daniels M. J., Y. M. Wang, M. Y. Lee và A. R. Venkitaraman (2004). Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 306(5697):876-879.
Danthine S., C. Blecker, M. Paquot, N. Innocente và C. Deroanne (2000). Progress in milk fat globule membrane research: a review. Lait 80(2):209-222.
Deeth H. C. 1997. The role of phospholipids in the stability of milk fat globules. Australian Journal of Dairy Technology 52(1):44-46.
Dewettinck K., R. Rombaut, N. Thienpont, T. T. Le, K. Messens và J. V. Camp. (2008). Nutritional and technological aspects of milk fat globule membrane material. Int. Dairy J. 18:436-457.
Duivenvoorden I., P. J. Voshol, P. C. N. Rensen, W. van Duyvenvoorde, J. A. Romijn, J. J. Emeis, L. M. Havekes và W. F. Nieuwenhuizen (2006). Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice. Am. J. Clin. Nutr. 84(2):312-321.
Fong B. Y., C. S. Norris và A. K. H. MacGibbon (2007). Protein and lipid composition of bovine milk-fat-globule membrane. International Dairy Journal 17:275-288.
Gaitonde P., A. Peng, R. M. Straubinger, R. B. Bankert và S. V. Balu-Iyer (2011). Phosphatidylserine reduces immune response against human recombinant Factor VIII in Hemophilia A mice by regulation of dendritic cell function. Clinical Immunology 138(2):135-145.
Guggenmos J., A. S. Schubart, S. Ogg, M. Andersson, T. Olsson, I. H. Mather và C. Linington (2004). Antibody Cross-Reactivity between Myelin Oligodendrocyte Glycoprotein and the Milk Protein Butyrophilin in Multiple Sclerosis. The Journal of Immunology 172(1):661-668.
Habte H. H., C. de Beer, Z. E. Lotz, M. G. Tyler, D. Kahn và A. S. Mall. (2008). Inhibition of human immunodeficiency virus type 1 activity by purified human breast milk mucin (MUC1) in an inhibition assay. Neonatology 93(3):162-170.
Hartmann P., A. Szabo, G. Eros, D. Gurabi, G. Horvath, I. Nemeth, M. Ghyczy và M. Boros (2009). Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats. Eur. J. Pharmacol. 622(1-3):58-64.
Idota T. và H. Kawakami. 1995. Inhibitory Effects of Milk Ganglioside on the Adhesion of Escherichia Colito Human Intestinal Carcinoma Cells. Bioscience Biotechnology and Biochemistry 59(1):69-72.
Inagaki M., S. Nagai, T. Yabe, S. Nagaoka, N. Minamoto, T. Takahashi, T. Matsuda, O. Nakagomi, T. Nakagomi, T. Ebina và Y. Kanamaru (2010). The Bovine Lactophorin C-Terminal Fragment and PAS6/7 Were Both Potent in the Inhibition of Human Rotavirus Replication in Cultured Epithelial Cells and the Prevention of Experimental Gastroenteritis. Biosci. Biotechnol. Biochem. 74(7):1386-1390.
Ito O., S. Kamata, M. Hayashi và K. Ushiyama (1993). Milk Fat Globule Membrane Substances Inhibit Mouse Intestinal Beta-Glucuronidase. J. Food Sci. 58(4):753-755.
Johns T. G. và C. C. A. Bernard (1999). The structure and function of myelin oligodendrocyte glycoprotein. J. Neurochem. 72(1):1-9.
Jorissen B. L., F. Brouns, M. P. Van Boxtel và W. J. Riedel (2002). Safety of soy-derived phosphatidylserine in elderly people. Nutr Neurosci 5(5):337-343.
Kanno C. (1990). Secretory Membranes of the Lactating Mammary-Gland. Protoplasma 159(2-3):184-208.
Kidd P. M. 2002a. Phosphatidylcholine (Monograph). Alternative Medicine Review 7(2):150-154.
Kidd P. M. (2002b). Phospholipids: Versatile nutraceutical ingredients for functional foods. Functional Foods and Nutraceuticals 12:30-40.
Kingsley M. 2006. Effects of phosphatidylserine supplementation on exercising humans. Sports Medicine 36(8):657-669.
Kvistgaard A. S., L. T. Pallesen, C. F. Arias, S. Lopez, T. E. Petersen, C. W. Heegaard và J. T. Rasmussen (2004). Inhibitory effects of human and bovine milk constituents on rotavirus infections. J. Dairy Sci. 87(12):4088-4096.
Le T. T. (2012). Purification, Analysis and Applications of Bioactive Milk Fat Globule Membrane Material. Page 257. Vol. PhD. Ghent University, Gent.
Le T. T., J. Miocinovic, T. M. Nguyen, R. Rombaut, J. Van Camp và K. Dewettinck (2011a). Improved Solvent Extraction Procedure and High-Performance Liquid Chromatography-Evaporative Light-Scattering Detector Method for Analysis of Polar Lipids from Dairy Materials. J. Agric. Food Chem. 59(19):10407-10413.
Le T. T., J. Miocinovic, J. Van Camp, B. Devreese, K. Struijs, T. Van de Wiele và K. Dewettinck (2010). Isolation and Applications of Milk Fat Globule Membrane Material: Isolation from Buttermilk and Butter Serum. Communications in Agricultural and Applied Biological Sciences, Ghent University 76(1):111-114.
Le T. T., J. van Camp, P. A. L. Pascual, G. Meesen, N. Thienpont, K. Messens và K. Dewettinck (2011b). Physical properties and microstructure of yoghurt enriched with milk fat globule membrane material. International Dairy Journal 21:798-805.
Le T. T., J. Van Camp, R. Rombaut, F. van Leeckwyck và K. Dewettinck (2009). Effect of washing conditions on the recovery of milk fat globule membrane proteins during the isolation of milk fat globule membrane from milk. J. Dairy Sci. 92(8):3592-3603.
Le T. T., T. Van de Wiele, T. N. H. Do, G. Debyser, K. Struijs, B. Devreese, K. Dewettinck và J. Van Camp. (2012). Stability of milk fat globule membrane proteins towards human enzymatic gastrointestinal digestion. J. Dairy Sci. 95:2307-2318.
Martin H. M., J. T. Hancock, V. Salisbury và R. Harrison (2004). Role of xanthine oxidoreductase as an antimicrobial agent. Infect. Immun. 72(9):4933-4939.
Mather I. H. (2000). A Review and proposed nomenclature for major proteins of the milk-fat globule membrane. J. Dairy Sci. 83:203-247.
McJarrow P., N. Schnell, J. Jumpsen và T. Clandinin (2009). Influence of dietary gangliosides on neonatal brain development. Nutrition Reviews 67(8):451-463.
Michalski M. C., V. Briard, F. Michel, F. Tasson và P. Poulain (2005). Size distribution of fat globules in human colostrum, breast milk, and infant formula. J. Dairy Sci. 88(6):1927-1940.
Niederau C., G. Strohmeyer, T. Heintges, K. Peter và E. Göpfert (1998) Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double-blind, placebo-controlled trial. Hepatogastroenterology 45(21):797-804.
Noh S. K. và S. I. Koo (2004). Milk Sphingomyelin Is More Effective than Egg Sphingomyelin in Inhibiting Intestinal Absorption of Cholesterol and Fat in Rats. Nutrition Metabolism 134(10):2611-2616.
Ohlsson L., H. Burling và A. Nilsson (2009). Long term effects on human plasma lipoproteins of a formulation enriched in butter milk polar lipid. Lipids in Health and Disease 8(44).
Oshida K., T. Shimizu, M. Takase, Y. Tamura và Y. Yamashiro. 2003. Effects of dietary sphingomyelin on central nervous system myelination in developing rats. Pediatr. Res. 53(4):589-593.
Park E. J., M. Suh, A. B. R. Thomson, K. S. Ramanujam và M. T. Clandinin (2006). Dietary gangliosides increase the content and molecular percentage of ether phospholipids containing 20 : 4n-6 and 22 : 6n-3 in weanling rat intestine. Journal of Nutritional Biochemistry 17(5):337-344.
Parker P., L. Sando, R. Pearson, K. Kongsuwan, R. L. Tellam và S. Smith (2010). Bovine Muc1 inhibits binding of enteric bacteria to Caco-2 cells. Glycoconjugate Journal 27(1):89-97.
Pepeu G., I. M. Pepeu và L. Amaducci (1996). A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pharmacol. Res. 33(2):73-80.
Riccio P. (2004). The proteins of the milk fat globule membrane in the balance. Trends in Food Science & Technology 15(9):458-461.
Rombaut R. (2006). Enrichment of nutritionally advantageous milk fat globule membrane fragments present in dairy effluents. Page 228. Vol. PhD. Ghent Uni., Ghent.
Rueda R. (2007). The role of dietary gangliosides on immunity and the prevention of infection. Br. J. Nutr. 98:S68-S73.
Rueda R., J. L. Sabatel, J. Maldonado, J. A. Molina-Font và A. Gil. (1998). Addition of gangliosides to an adapted milk formula modifies levels of fecal Escherichia coliin preterm newborn infants. The Journal of Pediatrics 133(1):90-94.
Ruvoen-Clouet N., E. Mas, S. Marionneau, P. Guillon, D. Lombardo và J. L. Pendu (2006). Bile-salt-stimulated lipase and mucins from milk of 'secretor' mothers inhibit the binding of Norwalk virus capsids to their carbohydrate ligands. Biochem. J. 393:627-634.
Sachdeva S. và W. Buchheim (1997). Recovery of phospholipids from buttermilk using membrane processing. Kieler Milchw. Forsch. 49:47-68.
Saeland E., M. A. W. P. de Jong, A. A. Nabatov, H. Kalay, T. B. H. Geijtenbeek và Y. van Kooyk (2009). MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells. Mol. Immunol. 46(11-12):2309-2316.
Schmelz E. M., D. L. Dillehay, S. K. Webb, A. Reiter, J. Adams và A. H. Merrill (1996). Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: Implications for dietary sphingolipids and colon carcinogenesis. Cancer Res. 56(21):4936-4941.
Shahriar F., M. Ngeleka, J. R. Gordon và E. Simko (2006). Identification by mass spectroscopy of F4ac-fimbrial-binding proteins in porcine milk and characterization of lactadherin as an inhibitor of F4ac-positive Escherichia coliattachment to intestinal villi in vitro. Dev. Comp. Immunol. 30(8):723-734.
Snow D. R., R. Jimenez-Flores, R. E. Ward, J. Cambell, M. J. Young, I. Nemere và K. J. Hintze (2010). Dietary Milk Fat Globule Membrane Reduces the Incidence of Aberrant Crypt Foci in Fischer-344 Rats. J. Agric. Food Chem. 58(4):2157-2163.
Snow L. D., D. G. Colton và K. L. Carraway (1977). Purification and properties of the major sialoglycoprotein of the milk fat globule membrane. Arch. Biochem. Biophys. 179(2):290-697.
Spitsberg V. L. (2005). Invited review: Bovine milk fat globule membrane as a potential nutraceutical. J. Dairy Sci. 88:2289 - 2294.
Spitsberg V. L. và R. C. Gorewit (1997). In vitro phosphorylated bovine milk fat globule membrane proteins. Journal of Nutritional Biochemistry 8(4):181-189.
Spitsberg V. L. và R. C. Gorewit (2002). Isolation, purification and characterization of fatty-acid-binding protein from milk fat globule membrane: Effect of bovine growth hormone treatment. Pakistan Journal of Nutrition 1(1):43-48.
Spitsberg, V. L., E. Matitashvili và R. C. Gorewit (1995). Association and coexpression of fatty-acid-binding protein and glycoprotein CD36 in the bovine mammary gland Eur. J. Biochem. 230:872-878.
Sprong R. C., M. F. E. Hulstein và R. van der Meer (2002). Bovine milk fat components inhibit food-borne pathogens. International Dairy Journal 12(2-3):209-215.
Starks M. A., S. L. Starks, M. Kingsley, M. Purpura và R. Jager (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr 5(11).
Stefferl A., A. Schubart, M. Storch2, A. Amini, I. Mather, H. Lassmann và C. Linington (2000). Butyrophilin, a Milk Protein, Modulates the Encephalitogenic T Cell Response to Myelin Oligodendrocyte Glycoprotein in Experimental Autoimmune Encephalomyelitis. The Journal of Immunology 165(5):2859-2865.
Stremmel W., A. Braun, A. Hanemann, R. Ehehalt, F. Autschbach và M. Karner (2010). Delayed Release Phosphatidylcholine in Chronic-active Ulcerative Colitis A Randomized, Double-blinded, Dose Finding Study. Journal of Clinical Gastroenterology 44(5):E101-E107.
Suh M., M. Belosevic và M. T. Clandinin (2004). Dietary lipids containing gangliosides reduce Giardia muris infection in vivo and survival of Giardia lamblia trophozoites in vitro. Parasitology 128:595-602.
Tokes T., G. Eros, S. Varszegi, P. Hartmann, A. Bebes, J. Kaszaki, K. Gulya và M. Boros (2010). Protective effects of phosphatidylcholine pretreatment in endotoxin-induced systemic inflammation in the rat hippocampus. Acta Physiologica Hungarica 97(4):483-483.
Vaisman N., N. Kaysar, Y. Zaruk-Adasha, D. Pelled, G. Brichon, G. Zwingelstein và J. Bodennec (2008). Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids. Am. J. Clin. Nutr. 87(5):1170-1180.
Vazquez E., A. Gil và R. Rueda (2001). Dietary gangliosides positively modulate the percentages of Th1 and Th2 lymphocyte subsets in small intestine of mice at weaning. Biofactors 15(1):1-9.
Vissac C., D. Lemery, L. Le Corre, P. Fustier, P. Dechelotte, J. C. Maurizis, Y. J. Bignon và D. J. Bernard-Gallon (2002). Presence of BRCA1 and BRCA2 proteins in human milk fat globules after delivery. Biochimica Et Biophysica Acta-Molecular Basis of Disease 1586(1):50-56.
Vojdani A., A. W. Campbell, E. Anyanwu, A. Kashanian, K. Bock và E. Vojdani (2002). Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. Journal of Neuroimmunology 129(1-2):168-177.
Wada A., M. Hasegawa, P. F. Wong, E. Shirai, N. Shirai, L. J. Tan, R. Llanes, H. Hojo, E. Yamasaki, A. Ichinose, Y. Ichinose và M. Senba (2010). Direct binding of gangliosides to Helicobacter pylorivacuolating cytotoxin (VacA) neutralizes its toxin activity. Glycobiology 20(6):668-678.
Walstra P. (1985). Some comments on the isolation of fat globule membrane material. Journal of Dairy Research 52:309-312.
Walstra P., J. T. M. Wouters và T. J. Geurts (2006). Dairy Science and Technology. 2nd ed. CRC Press, Florida.
Wang B., J. Brand-Miller, P. McVeagh và P. Petocz (2001a). Concentration and distribution of sialic acid in human milk and infant formulas. Am. J. Clin. Nutr. 74(4):510-515.
Wang B., J. B. Miller, Y. McNeil và P. McVeagh (1998). Sialic acid concentration of brain gangliosides: Variation among eight mammalian species. Comp Biochem Phys A 119(1):435-439.
Wang, B., B. Yu, M. Karim, H. Hu, Y. Sun, P. McGreevy, P. Petocz, S. Held và J. Brand-Miller (2007). Dietary sialic acid supplementation improves learning and memory in piglets. Am. J. Clin. Nutr. 85(2):561-569.
Wang X., S. Hirmo, R. Willen và T. Wadstrom (2001b). Inhibition of Helicobacter pyloriinfection by bovine milk glycoconjugates in a BALB/cA mouse model. J. Med. Microbiol. 50(5):430-435.
Whanger, P. D. 2004. Selenium and its relationship to cancer: an update. Br. J. Nutr. 91(1):11-28.
Yabe U., C. Sato, T. Matsuda và K. Kitajima (2003). Polysialic acid in human milk - CD36 is a new member of mammalian polysialic acid-containing glycoprotein. J. Biol. Chem. 278(16):13875-13880.
Ye A., H. Singh, M. W. Taylor và S. Anema (2002). Characterization of protein components of natural and heat-treated milk fat globule membranes. International Dairy Journal 12:393-402.
Yolken R. H., J. A. Peterson, S. L. Vonderfecht, E. T. Fouts, K. Midthun và D. S. Newburg (1992). Human-Milk Mucin Inhibits Rotavirus Replication and Prevents Experimental Gastroenteritis. J. Clin. Invest. 90(5):1984-1991.
Yolken R. H., R. Willoughby, S. B. Wee, R. Miskuff và S. Vonderfecht (1987). Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses. J Clin Invest. 79(1):148.