Pathological Characteristics of the DogsCaused by CareVirus (CDV-768)

Canine distemper (CD)is an acute infectious disease caused by virusin dogs. Results of infecting virus strain Care (CDV-768) for three Berger doghybrids at2 months of age adose 106TCID50/25µlthrough the eyes, mouth,and nebulizationshowed thatinfected dogs showedsymptoms of moodiness, fatigue, appetite loss, fever, vomiting, diarrhea, and bloody diarrhea with sketchy notes on the skin, thickening/keratinizing of the soles of the feet. The macroscopic pathological lesions were found mainly in the lungs (pulmonary sectional epidemic, lung incarnate), intestinal hyperemia phenomena, hemorrhage, brain hemorrhage, swollen lymph nodes, liver degeneration, and swollen gallbladder. The microscopicpathological signs includedred blood cells inside alveoli, alveolar walls rupture, parenchymal cell degeneration, torn crushed villi,and inflammatory cell infiltration in the brain. Virus concentrated mainly in the lungs, lymph nodesandintestines. The experimental results showedthat virus strain Care (CDV-768)was highly virulentand potentially pathogenic for dogs.