POLYMORPHISM IN EXON 14 OF ANTIVIRAL RESISTANT MX GENEIN VIETNAMESE INDIGENOUS CHICKEN BREEDS

Ngày nhận bài: 05-05-2013

Ngày duyệt đăng: 25-08-2013

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Số: Tập 11 Số 5 (2013)

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CHĂN NUÔI – THÚ Y – THỦY SẢN

Cách trích dẫn:

Đào, B., Liên, Đồng, Thảo, N., & Desmecht, D. (2024). POLYMORPHISM IN EXON 14 OF ANTIVIRAL RESISTANT MX GENEIN VIETNAMESE INDIGENOUS CHICKEN BREEDS. Tạp Chí Khoa học Nông nghiệp Việt Nam, 11(5), 635–640. http://testtapchi.vnua.edu.vn/index.php/vjasvn/article/view/55

POLYMORPHISM IN EXON 14 OF ANTIVIRAL RESISTANT MX GENEIN VIETNAMESE INDIGENOUS CHICKEN BREEDS

Bùi Trần Anh Đào (*) 1 , Đồng Thị Hồng Liên 2 , Nguyễn Thị Phương Thảo 3 , Daniel Desmecht 4

  • 1 Department of Veterinary Pathology, Faculty of Veterinary Medicine
  • 2 Center for Experiment and Vocational Training, Hanoi University of Agriculture, Vietnam
  • 3 Faculty of Biotechnology, Hanoi University of Agriculture, Vietnam
  • 4 Department of Morphopathology, Faculty of Veterinary Medicine, University of Liege, Belgium

    • Từ khóa

    Exon 14, indigenous chickens, Mx gene, nucleotide polymorphism, Vietnam, Việt Nam

    Tóm tắt


    The study was conducted to analyze the nucleotide polymorphisms of exon 14, Mx gene of seven Vietnamese indigenous chicken breedsL viz. Ac, Dong Tao, H’mong, Ho, Mia, Mong and Ri. The results revealed that the polymorphisms of exon 14 occured at two sites (2032th and 2159th). The non-synonymous substitution A/G at nucleotide 2032th of Mx gene was found in all of seven indigenous breeds used in this study. In the same breed, both of alleles A and G were present, however, allele A (viral resistance) was at a higher frequency than allele G (viral susceptiblity). Particularly, the allele A frequency of Ri and H’mong was highest among 7 breeds examined (80.91% and 74.04%, respectively). Comparative analysis of the deduced amino acids showed that 2032 A/G polymorphism altered amino acid substitution at site 631 of Mx protein of Asparagine (related to viral resistance) by Serine (lack of potent for viral resistance).

    Tài liệu tham khảo

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